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Predict the ln(IC50) of a peptide based on its sequence.

The IC50 (in nM unit) of a ligand is the concentration required to displace 50% of a reference ligand from a receptor. The receptor is a HLA-A2 MHC molecule. The reference peptide used here is ALAKAAAAV (Kd = 170 nM) for 9mers and ALAKAAAAAV (Kd = 1667 nM) for 10mers.
Note that if IC50 = 50 nM, ln(IC50) = 3.91.

Enter a 9- or 10-residue-long peptide sequence (eg. AAAAKAAAA) to predict the ln(IC50) for the HLA-A2 allele:


Prediction of the best HLA-A2 binding peptide(s) from an input protein sequence.

Enter a protein sequence from which HLA-A2-binding 9mers and 10mers will be predicted:

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Prediction of mutant peptide(s) that bind better than the wild type while sharing its T cell epitope.

Enter a 9-residue or a 10-residue peptide sequence (eg. AAAAAAKAA):

Indicate which positions are to be un-altered:

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Protein Engineering