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CARRIE Overview

Computational Ascertainment of Regulatory Relationships Inferred from Expression

The CARRIE Web Service can automatically infer a hypothetical transcriptional regulatory network from microarray and promoter sequence data. Given microarray data that show the changes in expression between two conditions, say before and after stimulating some cellular receptor, CARRIE can determine which genes showed changes in gene expression in response to that stimulus, which transcription factors are the most likely to have regulated that expression change, and specifically which transcription factor or factors were most likely to regulate each gene. The resulting network is displayed in an interactive format that includes additional sources of data that can assist in forming hypotheses about the network.

Protein Engineering